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鏉ユ仼鐢熺墿鍖昏嵂鏈夐檺鍏徃绠€浠�<\/b><\/p> \n

鏉ユ仼鐢熺墿鍖昏嵂鏈夐檺鍏徃锛圠ion TCR Pte Ltd锛夋槸涓€瀹朵笓娉ㄤ簬T缁嗚優鍏嶇柅娌荤枟鐨勪复搴婇樁娈电殑鐢熺墿绉戞妧鍏徃锛岀敤浜庢不鐤楃檶鐥囧拰鐥呮瘨寮曡捣鐨勭柧鐥呫€傛垜浠嚧鍔涗簬寮€鍙戝拰鍟嗕笟鍖栧師鍒涗笌鏂板瀷鐨勫厤鐤不鐤椾骇鍝併€傛垜浠殑鍏抽敭鍏嶇柅娌荤枟鎶€鏈钩鍙版秹鍙奣CR-T鐩稿叧鐨凾CR鍙戠幇骞冲彴锛岃嚜浣撱€佸紓浣撶粏鑳炲钩鍙颁互鍙婂熀鍥犵紪杈戞妧鏈钩鍙帮紝鍏朵腑鍏ㄧ悆棣栧垱锛團irst in Class锛夌殑閽堝HBV鐥呮瘨闈剁偣鐨凾CR鎶€鏈幏寰楁柊鍔犲潯绉戞妧鐮旂┒灞€锛圓*STAR锛夌殑鍏ㄧ悆鐙鍟嗕笟鎺堟潈銆傛牳蹇冪绾块拡瀵圭殑閫傚簲鐥囦负瀹炰綋鐦や緥濡傝倽缁嗚優鐧岋紝浠ュ強鐥呮瘨寮曡捣鐨勭柧鐥呬緥濡傛參鎬т箼鑲濈梾姣掓劅鏌撶瓑銆傛潵鎭╃敓鐗╂嫢鏈夊畬鍠勭殑涓撳埄淇濇姢锛屽紑灞曞苟瀹屾垚浜嗗叏鐞冮涓澏鍚慔BV鎶楀師娌荤枟鑲濈粏鑳炵檶鐨凾CR-T涓村簥璇曢獙銆�<\/p> \n

榫欏ご浜у搧<\/b>LioCyx-M004<\/b>绠€浠�<\/b><\/p> \n

LioCyx-M004鏄粡杩囦慨楗板彲琛ㄨ揪涔欒倽鐥呮瘨锛圚BV锛夌壒寮傛€缁嗚優鍙椾綋锛圱CR锛夌殑鑷綋T缁嗚優銆備复搴婂墠鐮旂┒鍜屼复搴婄爺绌舵暟鎹兘鏄剧ず杩欎簺缁忚繃淇グ鐨凾缁嗚優鑳藉璇嗗埆骞朵笖鏉€鐏箼鑲濈梾姣掓劅鏌撶殑鑲濈檶缁嗚優銆� <\/p> \n

鏉ユ仼鑱旂粶浜�<\/b><\/p> \n

涓浗鍖哄煙鑱旂粶浜�
鍛ㄨ蕉鍗氬+
鎴樼暐涓庝笟鍔″彂灞曞壇鎬荤洃
鐢佃瘽锛�+86 15994719201
鐢甸偖锛�zhouyi@liontcr.com<\/a><\/p> \n

娴峰鍖哄煙鑱旂粶浜�
Regina Wong锛堢帇濠夊锛夊崥澹�
涓氬姟鍙戝睍缁忕悊
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regina.wong@liontcr.com<\/a><\/p> \n

鍙傝€冩枃鐚細<\/p> \n

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  1. Koh et al, Mol. Ther., 鈥淎 practical approach to immunotherapy of hepatocellular carcinoma using T cells redirected against hepatitis B virus鈥�, Nucleic Acids, 2013; <\/li> \n
  2. Kah et al, J. Clin. 鈥淟ymphocytes transiently expressing virus-specific T cell receptors reduce hepatitis B virus infection鈥�, Invest., 2017;  <\/li> \n
  3. Tan et al, 鈥淯se of Expression Profiles of HBV-DNA Integrated Into Genomes of Hepatocellular Carcinoma Cells to Select T Cells for Immunotherapy鈥�, Gastroenterology, 2019; <\/li> \n
  4. Chen W et al. 鈥淧hase I Study of LioCyx-M, Autologous Hepatitis B Virus (HBV)-Specific T cell receptor (TCR) T-cells, in Recurrent HBV-Related Hepatocellular Carcinoma (HCC) Post-Liver Transplantation鈥�, Journal for ImmunoTherapy of Cancer, 2020; <\/li> \n
  5. Fu-Sheng Wang<\/span> et al. 鈥淧065 Phase 1 study of autologous hepatitis B virus (HBV) specific T cell receptor (TCR) T cells, LioCyx M in unresectable HBV related hepatocellular carcinoma (HCC).鈥�, EASL Digital Liver Cancer Summit 2021.<\/span><\/li> \n<\/ol> \n
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