鍏充簬鑺︽瘮鏇垮畾<\/u><\/b><\/p> \n
鑺︽瘮鏇垮畾鏄粠娴烽灅 Ecteinacidia turbinata <\/i>涓垎绂诲嚭鐨勬捣娲嬪寲鍚堢墿ET-736鐨勮鐢熺墿锛孍T-736涓殑姘㈠師瀛愯鐢叉哀鍩哄彇浠ｃ€傝姦姣旀浛瀹氳兘澶熼€夋嫨鎬у湴鎶戝埗澶氱鑲跨槫鎵€渚濊禆鐨勮嚧鐧屽熀鍥犺浆褰曘€傞櫎浜嗗叾瀵圭檶缁嗚優鐨勭洿鎺ヤ綔鐢紝鑺︽瘮鏇垮畾杩樿兘澶熸姂鍒惰偪鐦ょ浉鍏冲法鍣粏鑳炵殑杞綍杩囩▼锛屼互鍙婁笅璋冨鑲跨槫鐢熼暱鑷冲叧閲嶈鐨勭粏鑳炲洜瀛愮殑浜х敓銆�<\/p> \n
缁у湪缇庡浗鑾峰緱闄勬潯浠舵壒鍑嗙敤浜庢不鐤楄浆绉绘€у皬缁嗚優鑲虹檶鍚庯紝鑺︽瘮鏇垮畾杩樺湪9涓浗瀹惰幏鎵逛笂甯傦紝骞跺凡鑾峰緱ESMO灏忕粏鑳炶偤鐧屾寚鍗楋紙2021鐗堬級銆丯CCN灏忕粏鑳炶偤鐧屾寚鍗楋紙2022鐗堬級鍜�2023骞翠腑鍥戒复搴婅偪鐦ゅ浼氾紙CSCO锛夊皬缁嗚優鑲虹檶鎸囧崡鎺ㄨ崘銆傜豢鍙跺埗鑽泦鍥㈡嫢鏈夎姦姣旀浛瀹氱殑涓浗鏉冪泭銆�<\/p> \n
鍏充簬缁垮彾鍒惰嵂闆嗗洟<\/u><\/b><\/p> \n
缁垮彾鍒惰嵂闆嗗洟鏄嚧鍔涗簬鍒涙柊鑽墿鐨勭爺鍙戙€佺敓浜у拰閿€鍞殑鍥介檯鍖栧埗鑽叕鍙搞€傜豢鍙跺埗鑽湪涓浗銆佺編鍥藉拰娆ф床璁炬湁鐮斿彂涓績锛屾嫢鏈夎秴杩�30涓腑鍥藉湪鐮旇嵂鐗╁拰10澶氫釜娴峰鍦ㄧ爺鑽墿銆傜豢鍙跺埗鑽湪寰悆銆佽剛璐ㄤ綋銆侀€忕毊閲婅嵂绛夊厛杩涜嵂鐗╅€掗€佹妧鏈鍩熻揪鍒板浗闄呭厛杩涙按骞筹紝鍦ㄦ柊鍒嗗瓙瀹炰綋銆佺敓鐗╂姉浣撻鍩熸敹鑾峰椤瑰垱鏂版垚鏋滐紝骞跺湪缁嗚優娌荤枟銆佸熀鍥犳不鐤楃瓑棰嗗煙杩涜浜嗙Н鏋佸竷灞€鍜屽紑鍙戙€�<\/p> \n
缁垮彾鍒惰嵂娣卞害甯冨眬鍏ㄧ悆渚涘簲閾句綋绯伙紝宸插湪鍏ㄧ悆寤烘湁8澶х敓浜у熀鍦帮紝瓒呰繃30鏉＄敓浜х嚎锛屽苟寤虹珛浜嗕笌鍥介檯鎺ヨ建鐨凣MP璐ㄩ噺绠＄悊鍜屾帶鍒朵綋绯汇€傚叕鍙哥幇鏈�30浣欎釜涓婂競浜у搧锛屼骇鍝佽鐩栬偪鐦ゃ€佷腑鏋㈢缁忕郴缁熴€佸績琛€绠°€佹秷鍖栦笌浠ｈ阿绛夋不鐤楅鍩燂紱涓氬姟閬嶅強鍏ㄧ悆80澶氫釜鍥藉鍜屽湴鍖猴紝鍏朵腑鍖呮嫭涓浗銆佺編鍥姐€佹娲层€佹棩鏈瓑鍏ㄧ悆涓昏鍖昏嵂甯傚満锛屼互鍙婇珮閫熷闀跨殑鍚勫湴鏂板叴甯傚満銆�<\/p> \n
鍏充簬<\/u><\/b>PharmaMar<\/u><\/b><\/p> \n
PharmaMar鏄竴瀹朵笓娉ㄤ簬鐮旂┒鍜屽紑鍙戝垱鏂拌偪鐦ゆ不鐤楁柟妗堢殑鐢熺墿鍒惰嵂鍏徃锛屽叾浣垮懡鏄鍒涙柊鑽墿鎯犲強閲嶅ぇ鐤剧梾鎮ｈ€咃紝甯姪鍏舵彁鍗囦复搴婅幏鐩娿€侾harmaMar浠ユ捣娲嬩负婧愶紝浠ョ瀛︿负椹卞姩鍔涳紝浠ユ偅鑰呬负瀵煎悜锛岄€氳繃鎻愪緵鍒涙柊鑽墿浠ユ敼鍠勯噸澶х柧鐥呮偅鑰呯殑鐢熸椿璐ㄩ噺锛屽苟鑷村姏浜庢寔缁垚涓烘捣娲嬭嵂鐗╁彂鐜般€佸紑鍙戝拰鍒涙柊鐨勫叏鐞冮瀵艰€呫€�<\/p> \n
PharmaMar宸茶嚜涓诲紑鍙戝苟鍦ㄦ娲插湴鍖哄晢涓氬寲Yondelis®<\/sup>銆佸湪缇庡浗鍙婁腑鍥戒笌鍚堜綔浼欎即鍚堜綔寮€鍙戝苟鍟嗕笟鍖朲epzelca®<\/sup>锛堣姦姣旀浛瀹氾級锛屽強鍦ㄦ境澶у埄浜氫笌鍚堜綔浼欎即鍚堜綔鍟嗕笟鍖朅plidin®<\/sup>(Plitidepsin)銆傛澶栵紝PharmaMar鎷ユ湁涓€绯诲垪鍊欓€夎嵂鐗┿€佸己澶х殑鑲跨槫鐮斿彂椤圭洰锛屽強閽堝澶氱瀹炰綋鐦ょ殑涓村簥鍦ㄧ爺椤圭洰锛屽寘鎷細鑺︽瘮鏇垮畾鍜孍cubectedin銆侾harmaMar鎬婚儴浣嶄簬瑗跨彮鐗欓┈寰烽噷锛屽苟鍦ㄥ痉鍥姐€佹硶鍥姐€佹剰澶у埄銆佹瘮鍒╂椂銆佸ゥ鍦板埄銆佺憺澹拰缇庡浗璁炬湁瀛愬叕鍙搞€傝嚧鍔涗簬鐮旂┒鍩哄洜娌夐粯(RNAi)鐤楁硶搴旂敤鐨勫叕鍙窼ylentis涓哄叾鍏ㄨ祫瀛愬叕鍙搞€�<\/p> \n
鍙傝€冩枃鐚細<\/p> \n
[1]. International Agency for Research on Cancer 鈥� Population Fact Sheets 鈥� China<\/span>. Available at https:\/\/gco.iarc.fr\/today\/data\/factsheets\/populations\/160-china-fact-sheets.pdf<\/a>. Accessed in June 2023<\/span>.
<\/sup>[2]. 涓浗涓村簥鑲跨槫瀛︿細鎸囧崡宸ヤ綔濮斿憳浼�. 涓浗涓村簥鑲跨槫瀛︿細锛圕SCO锛夊皬缁嗚優鑲虹檶璇婄枟鎸囧崡2022. 浜烘皯鍗敓鍑虹増绀�. 2022
<\/sup>[3]. Cancer.Net. Lung Cancer - Small Cell. Available at https:\/\/www.cancer.net\/cancer-types\/33776\/view-all<\/a>. Accessed in June 2023<\/span>.
<\/sup>[4]. Rudin CM, et al. Nat Rev Dis Primers. 2021 Jan 14;7(1):3.<\/sup><\/p> \n