鍏充簬鎷撹垝娌�<\/b>®<\/b>锛堣壘浼忓凹甯冪墖锛�<\/b><\/p> \n

鎷撹垝娌�^{®<\/sup>鏄竴绉嶉拡瀵笽DH1绐佸彉閰剁殑鍙ｆ湇闈跺悜鎶戝埗鍓傘€傛嫇鑸掓矁^{®<\/sup>宸茬粡鑾峰緱涓浗鍥藉鑽搧鐩戠潱绠＄悊灞€鎵瑰噯锛岀敤浜庢不鐤楁惡甯DH1鏄撴劅绐佸彉鐨勫鍙戞垨闅炬不鎬ф€ユ€ч珦绯荤櫧琛€鐥呮垚浜烘偅鑰呫€�<\/p> \n}}

鐩墠锛屾嫇鑸掓矁^{®<\/sup>宸插湪缇庡浗鑾锋壒锛岀敤浜庡崟鑽不鐤楁惡甯﹀紓鏌犳閰歌劚姘㈤叾1锛圛DH1锛夌獊鍙樼殑澶嶅彂鎴栭毦娌绘€ML鎴愪汉鎮ｈ€咃紝浠ュ強缁廎DA鎵瑰噯鐨勮瘯楠屾娴嬪嚭鐨勬柊璇婃柇鎼哄甫IDH1绐佸彉鐨凙ML鎴愪汉鎮ｈ€咃紙骞撮緞鈮�75宀佹垨浼存湁鍚堝苟鐥囨棤娉曟帴鍙楀己鍖栬瀵煎寲鐤楃殑鎮ｈ€咃級銆�2021骞达紝鎷撹垝娌�^{®<\/sup>鎴愪负鐩墠棣栦釜涓斿敮涓€鑾峰噯鐨勯澏鍚戠枟娉曪紝鐢ㄤ簬娌荤枟鏃㈠線鎺ュ彈杩囨不鐤楃殑銆佺粡FDA鎵瑰噯鐨勮瘯楠屾娴嬪嚭鐨勬惡甯DH1绐佸彉鐨勫眬閮ㄦ櫄鏈熸垨杞Щ鎬ц儐绠＄檶鎴愪汉鎮ｈ€呫€�2023骞达紝缇庡浗FDA鎵瑰噯鎷撹垝娌�^{®<\/sup>鑱斿悎闃挎墡鑳炶嫹鐢ㄤ簬娌荤枟IDH1鏄撴劅绐佸彉鐨勫鍙戞垨闅炬不鎬ч楂撳鐢熷紓甯哥患鍚堝緛锛圡DS锛夋垚浜烘偅鑰呫€�<\/p> \n}}}

鎷撹垝娌�^{®<\/sup>鍦ㄦ娲茶幏鎵逛綔涓轰袱椤归€傚簲鐥囩殑闈跺悜娌荤枟鑽墿锛氳仈鍚堥樋鎵庤優鑻风敤浜庢不鐤楁惡甯DH1 R132绐佸彉鐨勪笉閫傚悎鎺ュ彈鏍囧噯璇卞鍖栫枟鐨勬柊璇婃柇鐨凙ML鎴愪汉鎮ｈ€咃紱浠ュ強鍗曡嵂娌荤枟宸叉帴鍙楄繃鑷冲皯涓€绉嶇郴缁熺枟娉曠殑鎼哄甫IDH1 R132绐佸彉鐨勫眬閮ㄦ櫄鏈熸垨杞Щ鎬ц儐绠＄檶鎴愪汉鎮ｈ€呫€�<\/p> \n}

鏂界淮闆呮嫢鏈夋嫇鑸掓矁^{®<\/sup>鍦ㄥ叏鐞冭寖鍥村唴鐨勬墍鏈夋潈鍒┿€�<\/p> \n}

鎬ユ€ч珦绯荤櫧琛€鐥咃紙AML锛夋槸涓€绉嶇綍瑙佺柧鐥咃紝涓昏鍙戠敓鍦ㄨ€佸勾缇や綋銆侫ML鏄竴绉嶈娑插拰楠ㄩ珦鐧岀棁锛屽涓嶅強鏃舵不鐤楋紝鐥呮儏浼氳繀閫熸伓鍖栥€�<\/p> \n

AML鏄垚浜烘€ユ€х櫧琛€鐥呬腑鏈€甯歌鐨勭被鍨嬶紝娆ф床骞村彂鐥呯巼绾︿负5\/100,000浜猴紝鍗虫瘡骞存湁瓒呰繃2涓囦緥鏂板彂鐥呬緥[5]銆�75宀佹偅鑰呯殑涓ゅ勾鐢熷瓨鐜囦綆浜�10%[6]銆�<\/p> \n

鍦ㄤ腑鍥斤紝AML鍦ㄦ瘡骞存柊璇婃柇鐧岀棁鐥呬緥涓崰1%锛岀害鍗犳墍鏈夌櫧琛€鐥呰瘖鏂梾渚嬬殑涓€鍗婏紝姣忓勾瀵艰嚧22000浜烘浜°€俒7]<\/p> \n

鏍规嵁涓浗鍥藉鐧岀棁涓績鍙戝竷鐨勩€�2022骞村叏鍥界檶鐥囨姤鍛娿€嬶紝2000-2016骞存湡闂达紝鐧借鐥呮槸涓浗鐢锋€у彂鐥呯巼鍛堜笂鍗囪秼鍔跨殑涓夊ぇ鐧岀棁涔嬩竴锛屼粎娆′簬鍓嶅垪鑵虹檶鍜岀粨鐩磋偁鐧孾8]銆傜粺璁℃暟鎹樉绀猴紝涓浗姣忓勾绾︽湁8涓囦緥鐧借鐥呮柊鍙戞偅鑰匸9]銆侫ML鍙戠梾鐜囬殢鐫€骞撮緞鐨勫闀胯€屽鍔狅紝鍙兘褰卞搷鍚勪釜骞撮緞娈典汉缇ゃ€侫ML鍙戠梾蹇€佽繘灞曞揩銆佺敓瀛樼巼浣庛€傚钩鍧囧彂鐥呭勾榫勪负68宀侊紝45宀佷互涓嬩汉缇ゅ皯瑙侊紝鍙兘瑙佷簬鍎跨[10]銆�<\/p> \n

杩欑鐧岀棁鐢变竴绉嶆湭鎴愮啛缁嗚優鐨勫紓甯稿娈栧鑷达紝杩欎簺缁嗚優娌℃湁瀹屽叏鍙戣偛锛屽洜姝ゆ棤娉曞彂鎸ュ叾姝ｅ父浣滅敤銆傝繖浜涚檶缁嗚優瀛樺湪浜庤娑蹭腑锛屽洜姝よ绉颁负"鐧借鐥�"锛涜€屽洜涓哄畠浠捣婧愪簬楠ㄩ珦锛屽洜姝よ绉颁负"楂撶郴"銆傞楂撴槸浜轰綋楠ㄩ涓殑涓€绉嶇粍缁囷紝鏄骇鐢熻缁嗚優锛堢О涓�"姣嶇粏鑳�"锛夌殑閲嶈缁勭粐銆�<\/p> \n

鏂界淮闆呮槸涓€瀹剁敱鍩洪噾浼氱鐞嗙殑鍏ㄧ悆鎬у埗鑽泦鍥紝浠ユ湇鍔′汉绫诲仴搴蜂负瀹楁棬锛屾湡鏈涗负鎮ｈ€呭拰涓栫晫鍙寔缁彂灞曞甫鏉ユ剰涔夋繁杩滅殑绀句細褰卞搷銆備綔涓洪鎵硅繘鍏ヤ腑鍥界殑璺ㄥ浗鍒惰嵂浼佷笟涔嬩竴锛屾柦缁撮泤宸叉繁鑰曚腑鍥藉競鍦�45骞淬€傜粡杩囧嚑鍗佸勾鐨勭Н绱矇娣€锛屾柦缁撮泤涓浗宸茬粡鎴愪负涓€瀹跺厖婊℃椿鍔涚殑鍏徃锛屽湪蹇冭绠＄柧鐥呫€佺硸灏跨梾銆侀潤鑴夌柧鐥呯鐞嗘柟闈㈠眳浜庨鍏堝湴浣嶇殑鍚屾椂锛岀Н鏋佹嫇灞曡偪鐦ゅ棰嗗煙锛屽缁撶洿鑲犵檶銆佽兌璐ㄧ槫鍜屾恫浣撹偪鐦ゃ€傛柦缁撮泤鑷村姏浜庝负鏇村涓浗鎮ｈ€呮彁渚涢澏鍚戞不鐤楄嵂鐗╁拰瑙ｅ喅鏂规銆傛柦缁撮泤涓浗鎬婚儴浣嶄簬鍖椾含锛屾嫢鏈変竴鏀秴杩�1000浜虹殑寮哄ぇ涓撲笟鍥㈤槦銆�<\/p> \n

\n \n \n \n \n \n \n \n \n \n \n \n \n
[1] FDA News Release: https:\/\/www.fda.gov\/news-events\/press-announcements\/fda-approves-first-targeted-treatment-patients-relapsed-or-refractory-acute-myeloid-leukemia-who<\/span><\/p> <\/td> \n <\/tr> \n
[2] 鏍规嵁鍥藉鐧岀棁涓績銆�2016骞翠腑鍥界檶鐥囧彂鐥呯巼鍜屾浜＄巼銆嬬粺璁℃暟鎹�<\/span><\/p> <\/td> \n <\/tr> \n
[3] 鏉庨泤,闄堢憸,鏉庡啗姘�.鑰佸勾鎬ユ€ч珦绯荤櫧琛€鐥呯殑娌荤枟杩涘睍[J].鍐呯鐞嗚涓庡疄璺�,2019,14(06): 391-394.<\/span><\/p> <\/td> \n <\/tr> \n
[4] 鏂拌嫳鏍煎叞鍖诲鏉傚織锛�2018骞达紝378锛�25锛夛細2386-2398<\/span><\/p> <\/td> \n <\/tr> \n
[5] ESMO Guidelines 2020 - Acute myeloid leukemia in adult patients: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up<\/span><\/p> <\/td> \n <\/tr> \n
[6] National Cancer Institute. Surveillance, Epidemiology, and End Results (SEER) Program. Cancer Stat Facts: Acute Myeloid Leukemia (AML). https:\/\/seer.cancer.gov\/statfacts\/html\/amyl.html<\/span><\/p> <\/td> \n <\/tr> \n
[7] 鏉庨泤,闄堢憸,鏉庡啗姘�.鑰佸勾鎬ユ€ч珦绯荤櫧琛€鐥呯殑娌荤枟杩涘睍[J].鍐呯鐞嗚涓庡疄璺�,2019,14(06): 391-394.<\/span><\/p> <\/td> \n <\/tr> \n
[8] By National Cancer Center, 2022 National Cancer Report (phirda.com)<\/span><\/p> <\/td> \n <\/tr> \n
[9] GLOBOCAN Cancer Today Database, International Agency for Research on Cancer, World Health Organisation.Population Fact Sheets in 2018. Available at: http:\/\/gco.iarc.fr\/today\/data\/factsheets\/populations\/160-china-factsheets.pdf. Last accessed March 2020.<\/span><\/p> <\/td> \n <\/tr> \n
[10] https:\/\/www.cancer.org\/cancer\/acute-myeloid-leukemia\/about\/key-satatist<\/a><\/span><\/p> <\/td> \n <\/tr> \n <\/tbody> \n <\/table> \n<\/div>"]; $("#dvExtra").html(content_array[0]);})();