鍏充簬鎱㈡€ф穻宸寸粏鑳炵櫧琛€鐥�<\/u><\/b><\/p> \n
鎱㈡€ф穻宸寸粏鑳炵櫧琛€鐥咃紙CLL锛夋槸鎴愪汉涓渶甯歌鐨勭櫧琛€鐥呯被鍨嬶紝2019骞村叏鐞冩柊澧炵梾渚嬭秴杩�100,000渚�[5]<\/sup>銆傚敖绠℃湁浜汣LL鎮h€呭湪纭瘖鏃跺彲鑳芥病鏈変换浣曠棁鐘讹紝浣嗘湁浜涙偅鑰呭彲鑳戒細濡傝櫄寮便€佺柌鍔炽€佷綋閲嶅噺杞汇€佺晱瀵掋€佸彂鐑€佺洍姹椼€佹穻宸寸粨鑲垮ぇ鍜岃吂鐥涚殑鐥囩姸[6]<\/sup>銆傚湪CLL涓紝寮傚父娣嬪反缁嗚優鍦ㄨ娑层€侀楂撳拰娣嬪反缁撲腑绉仛銆傞殢鐫€寮傚父缁嗚優鏁伴噺鐨勫鍔狅紝楠ㄩ珦涓敤浜庝骇鐢熷仴搴风殑鐧界粏鑳炪€佺孩缁嗚優鍜岃灏忔澘鐨勭┖闂村噺灏�[7]<\/sup>銆傝繖鍙兘瀵艰嚧璐銆佹劅鏌撳拰鍑鸿銆傞€氳繃BTK锛堝竷椴侀】閰皑閰告縺閰讹級鐨凚缁嗚優鍙椾綋淇″彿浼犲鏄疌LL鐨勯噸瑕佺敓闀块€斿緞涔嬩竴銆�<\/p> \n
鍏充簬ChangE III鏈熶复搴婅瘯楠�<\/u><\/b><\/p> \n
ChangE 鏄竴椤圭敱涓浗鐗靛ご鐨勯殢鏈恒€佸涓績銆佸紑鏀炬爣绛� III 鏈熶复搴婅瘯楠岋紝鍏朵腑 66% 鐨勬偅鑰呮潵鑷腑鍥斤紙鍖呮嫭鍙版咕锛夛紝鍏朵綑锛�34%锛夋潵鑷嘲鍥姐€佽秺鍗楀拰鑿插緥瀹撅紙涓村簥璇曢獙鎵逛欢鍙凤細JXHL1900233锛夛紝璇ヨ瘯楠屾棬鍦ㄨ瘎浼伴樋鍙浛灏间笌鑻竵閰告爱鑺ヨ仈鍚堝埄濡ユ様鍗曟姉鐩告瘮锛屽鏈粡娌荤枟鐨� CLL 鎮h€呯殑瀹夊叏鎬у拰鏈夋晥鎬с€傚湪璇曢獙涓紝155 鍚嶆偅鑰呰闅忔満锛�1:1锛夊垎鎴愪袱缁勩€侫 缁勬偅鑰呮帴鍙楅樋鍙浛灏煎崟鑽不鐤楋紙100mg锛屾瘡鏃ヤ袱娆★紝鐩磋嚦鐥呮儏杩涘睍锛夈€侭 缁勬偅鑰呮帴鍙楄嫰涓侀吀姘姤鑱斿悎鍒╁Ε鏄斿崟鎶楁不鐤椼€�<\/p> \n
涓昏缁堢偣鏄� PFS锛岀敱鐩叉硶鐙珛涓ぎ瀹℃煡 (BICR) 璇勪及锛屾瑕佺粓鐐瑰寘鎷€讳綋缂撹В鐜囥€佺紦瑙f寔缁椂闂村拰鎬讳綋鐢熷瓨鏈�銆�<\/span><\/p> \n
鍏充簬闃垮彲鏇垮凹<\/u><\/b><\/p> \n
闃垮彲鏇垮凹鏄浜屼唬閫夋嫨鎬у竷椴侀】閰皑閰告縺閰讹紙BTK锛夋姂鍒跺墏銆傞樋鍙浛灏奸€氳繃涓嶣TK鍏变环缁撳悎锛屼粠鑰屾姂鍒跺叾娲绘€�[8]<\/span><\/sup>銆傚湪B缁嗚優涓紝BTK淇″彿瀵艰嚧B缁嗚優澧炴畺銆佽浆杩愩€佽秼鍖栧拰绮橀檮鎵€闇€鐨勯€斿緞婵€娲汇€�<\/p> \n
杩戝勾鏉ワ紝闅忕潃鐤剧梾鐮旂┒鐨勪笉鏂繁鍏ュ拰鏂板瀷闈跺悜鑽墿鐨勯閫熷彂灞曪紝CLL鐨勬不鐤楀凡杩堝叆闈跺悜鏃犲寲鐤楁椂浠c€侭TK鎶戝埗鍓備綔涓哄垱鏂扮枟娉曚箣涓€锛屼笉浠呬赴瀵屼簡鎮h€呯殑娌荤枟閫夋嫨锛屼篃涓哄欢闀垮叾PFS甯︽潵浜嗙‘鍒囩殑鑾风泭銆�<\/p> \n
闃垮彲鏇垮凹宸插湪鍏ㄧ悆琚敤浜庢不鐤楄秴杩�85,000鍚嶆偅鑰�[9]<\/span><\/sup>锛屽苟鍦ㄧ編鍥藉拰鏃ユ湰琚壒鍑嗙敤浜庢不鐤楁參鎬х粏娣嬪反缁嗚優鐧借鐥咃紙CLL锛塡/灏忔穻宸寸粏鑳炴穻宸寸槫 (SLL)锛屽湪娆х洘鍜屽叏鐞冭澶氬叾浠栧浗瀹跺湴鍖鸿鎵瑰噯鐢ㄤ簬娌荤枟CLL锛屽湪涓浗琚壒鍑嗙敤浜庢不鐤楀鍙戞垨闅炬不鎬LL\/SLL銆傞樋鍙浛灏煎湪缇庡浗銆佷腑鍥藉強鍏朵粬涓€浜涘浗瀹朵篃琚壒鍑嗙敤浜庢不鐤楄嚦灏戞帴鍙楄繃涓€绉嶆不鐤楃殑鎴愬勾濂楃粏鑳炴穻宸寸槫(MCL)鎮h€呫€傜洰鍓嶏紝闃垮彲鏇垮凹灏氭湭鍦ㄦ棩鏈垨娆х洘琚壒鍑嗙敤浜庢不鐤桵CL銆傜洰鍓嶏紝缇庡浗銆婂浗瀹剁患鍚堢檶鐥囩綉缁滐紙NCCN锛塁LL鎸囧崡銆嬪凡灏嗛樋鍙浛灏煎垪涓轰竴绾緾LL鐨勯閫夋不鐤椾箣涓€銆�<\/p> \n
浣滀负骞挎硾涓村簥寮€鍙戦」鐩殑涓€閮ㄥ垎锛岄樋鍙浛灏兼鍦ㄨ璇勪及鍗曠嫭鍜岃仈鍚堟爣鍑嗗厤鐤寲鐤楁柟妗堟不鐤楀绉岯缁嗚優琛€娑茶偪鐦わ紝鍖呮嫭CLL銆丮CL銆佸讥婕€уぇB缁嗚優娣嬪反鐦ゃ€�<\/p> \n
鍏充簬闃挎柉鍒╁悍鍦ㄨ娑茬梾棰嗗煙鐨勭爺绌�<\/u><\/b><\/p> \n
闃挎柉鍒╁悍姝e湪鎺ㄥ姩绉戝鐣岄噸鏂板畾涔夎娑茬柧鐥呯殑娌荤枟銆傛垜浠殑鐩爣鏄€氳繃鍩轰簬鎮h€呫€佹姢鐞嗕汉鍛樺拰鍖荤敓鐨勬礊瀵熸墍鎺ㄥ嚭鐨勫垱鏂拌嵂鐗╁拰鎵嬫锛屽府鍔╂敼鍙樻偅鏈夋伓鎬с€佺綍瑙佸強鍏朵粬鐩稿叧琛€娑茬柧鐥呯殑鎮h€呯殑鐢熸椿銆�<\/p> \n
闄や簡鎴戜滑宸蹭笂甯傜殑浜у搧澶栵紝鎴戜滑涔熷湪寮曢鐫€鏂扮枟娉曠殑寮€鍙戯紝杩欎簺鐤楁硶鏃ㄥ湪閫氳繃澶氫釜绉戝骞冲彴閿氬畾娼滃湪鐤剧梾杩涘睍鍥犵礌銆傞樋鏂埄搴烽€氳繃鏀惰喘Alexion浠ュ強浜樺枩鐢熺墿锛屽墠鑰呭湪缃曡鐨勯潪鎭舵€ц娑茬柧鐥呮柟闈㈠叿鏈変笓涓氫紭鍔匡紝鍚庤€呬笓娉ㄤ簬琛€娑叉伓鎬ц偪鐦ょ殑缁嗚優鐤楁硶锛屼粠鑰屾墿澶ц娑茬梾鐨勪骇鍝佺绾裤€傞€氳繃绔埌绔紑鍙戝拰鎻愪緵鏂板瀷鐤楁硶锛屽皢浣挎垜浠Е杈惧埌鏇村闇€姹傝繙鏈緱鍒版弧瓒崇殑鎮h€呫€�<\/p> \n
鍏充簬闃挎柉鍒╁悍鑲跨槫棰嗗煙鐨勭爺绌�<\/u><\/b><\/p> \n
闃挎柉鍒╁悍姝e紩棰嗙潃鑲跨槫棰嗗煙鐨勪竴鍦洪潻鍛斤紝鑷村姏鎻愪緵澶氬厓鍖栫殑鑲跨槫娌荤枟鏂规锛屼互绉戝鎺㈢储鑲跨槫棰嗗煙鐨勫鏉傛€э紝鍙戠幇銆佺爺鍙戝苟鍚戞偅鑰呮彁渚涙敼鍙樼敓鍛界殑鑽墿銆�<\/p> \n
闃挎柉鍒╁悍鐨勮偪鐦や笟鍔′笓娉ㄤ簬鏈€鍏锋寫鎴樻€х殑鑲跨槫鐤剧梾锛岄€氳繃鎸佺画涓嶆柇鐨勫垱鏂帮紝闃挎柉鍒╁悍宸茬粡寤虹珛浜嗛鍏堝叏琛屼笟鐨勫鍏冨寲浜у搧缁勫悎鍜屾笭閬擄紝鎸佺画鎺ㄥ姩鍖荤枟瀹炶返鍙橀潻锛屾敼鍙樻偅鑰呬綋楠屻€�<\/p> \n
闃挎柉鍒╁悍鐨勬効鏅棬鍦ㄩ噸鏂板畾涔夌檶鐥囨不鐤楋紝浠ユ湡鏈潵缁堢粨鐧岀棁杩欎竴鑷存涔嬪洜銆�<\/p> \n
澹版槑锛氶儴鍒嗙爺绌朵腑鐨勮嵂鍝佺敤娉曞皻鏈湪涓浗鑾锋壒閫傚簲鐥囷紝闃挎柉鍒╁悍涓嶆帹鑽愪换浣曟湭琚壒鍑嗙殑鑽搧浣跨敤銆�<\/i><\/b><\/p> \n
鍙傝€冩枃鐚�<\/b><\/p> \n
1. Lugui Qiu<\/span>, et al.2024 ASH.Abstract 3251.
2. https:\/\/www.cancer.gov\/types\/leukemia\/patient\/cll-treatment-pdq#_1<\/a>.
3. Guidelines for the Diagnosis and Treatment of Chronic Lymphocytic Leukemia\/Small Lymphocytic Lymphoma (2022 Edition)
4. Zhao Donglu, Ma Jun<\/span>. Advances in Research on First-line Treatment of Chronic Lymphocytic Leukemia [J]. Internal Medicine Theory and Practice, 2020,15(5):290-294. DOI:10.16138\/j.1673-6087.2020.05.003.
5. Yao Y, et al. The global burden and attributable risk factors of chronic lymphocytic leukemia in 204 countries and territories from 1990 to 2019: analysis based on the global burden of disease study 2019. Biomed Eng Online. 2022;1:4.
6. American Cancer Society. Signs and Symptoms of Chronic Lymphocytic Leukemia. Available at: https:\/\/www.cancer.org\/cancer\/types\/chronic-lymphocytic-leukemia\/detection-diagnosis-staging\/signs-symptoms.html<\/a>. Accessed November 2024<\/span>.
7. National Cancer Institute. Chronic lymphocytic leukemia treatment (PDQ)鈥揚atient version. Available at: https:\/\/www.cancer.gov\/types\/leukemia\/patient\/cll-treatment-pdq<\/a>. Accessed November 2024.®
8.<\/span> Wu J, et al. Acalabrutinib (ACP-196): a selective second-generation BTK inhibitor. J Hematol Oncol. 2016;9(21).
9.<\/span> Data on File, REF-236261. AstraZeneca Pharmaceuticals LP.<\/p>"];
$("#dvExtra").html(content_array[0]);})();